Resources

Certifications

To view Pillar Biosciences’ quality management system certificate for ISO 13485:2016 issued November 24, 2017 please click here.

Publications

    "Evaluation of a high-throughput NGS SLIMamp CFTR Assay" Advances in Genome Biology and Technology Personalized Health 2018 Poster

    To improve the robustness, efficiency and cost-effectiveness of cystic fibrosis transmembrane conductance regulator (CFTR) gene assays, we have applied our SLIMamp assay technology to enable up to 384-plex sequencing of the full coding region on a single MiSeq instrument run.

    148 variants were examined across 53 commercial samples with known variants, 47 clinical samples with known positive status and 5 Genome-in-a-Bottle (GIAB) samples.

    Register to Download 
    "Development and Evaluation of a Lung Cancer Fusion RNA Panel" Next Generation Diagnostics 2018 Poster

    This poster reviews the assay principle behind Pillar Biosciences’ Lung Cancer Fusion RNA Panel, the types of fusions interrogated, and presents results from 40 samples with known fusions from a variety of sources.

    Register to Download 
    Clinical and biomarker results from Phase I-II study of PI3K inhibitor BYL719 (Apelisib) plus Nab-paclitaxel in HER2-negative Metastatic Breast Cancer

    At the June 2018 American Society for Clinical Oncology conference held in Chicago IL (USA), the Kansas University Medical Center presented a poster describing the biomarker results of a Phase I-II clinical study of an experimental PI3K inhibitor called BYL719 (Apelisib) from Novartis.

    They used the ONCOReveal Multi-Cancer Panel from Pillar Biosciences on circulating cell-free DNA as part of their study. More information about this sensitive and efficient enrichment assay can be found here.

    Register to Download 
    "Application of ONCOREVEAL Lung & Colon Cancer Panel in CRC samples and effect of DNA damage in FFPE samples" AACR 2018 Conference Poster

    Access a poster presented by Jianfeng Xiao, Ph.D. at the April 2018 American Association for Cancer Research (AACR) in Chicago Illinois.

    The poster presents results from over 200 FFPE samples used for evaluating the performance of the Pillar Biosciences’ ONCOReveal Lung & Colon Cancer Panel, with a subset of 27 samples selected for further analysis for DNA artifacts and effectiveness of repair.

    Register to Download 
    A scientific poster presented by Dartmouth Hitchcock Medical Center at the Association for Molecular Pathology 2017

    Access this poster presented by Fran de Abreu, Ph.D. at the recent Association for Molecular Pathology conference in Salt Lake City, UT November 2017.

    The poster presents results from a total of 15 FFPE samples used for evaluating the performance of the Pillar Biosciences’ ONCO/Reveal Solid Tumor Panel, with the amount of genomic DNA input ranging from 17 – 72 ng and a total of 24 samples run on an Illumina MiSeq system using v3 chemistry.

    A median on-target rate of 99.57% and a median mapping rate of 99.11% are reported, with 100% concordance of previously reported results.

    Register to Download 
    Amplification of overlapping DNA amplicons in a single-tube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2

    This July 2017 PLOS One paper outlines Pillar Biosciences’ method and further development of the SLIMamp™ technology, and also describes the results of full-gene BRCA1 and BRCA2 panel as applied to cell line DNA and remnant human DNA samples.

    Schenk D, Song G, Ke Y, Wang Z (2017) Amplification of overlapping DNA amplicons in a singletube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2. PLOS ONE 12(7): e0181062. https://doi.org/10.1371/journal.pone.0181062

    Register to Download 
    "Evaluation of the Pillar NGS SLIMamp Lung and Colon Hot Spots Panel", a poster presented at the Association for Molecular Pathology 2016 in Charlotte, NC

    This poster was presented at the Association for Molecular Pathology 2016 conference held in Charlotte, NC and compared the performance of the Pillar Biosciences’ Lung and Colon Panel on an Illumina MiSeq™ to the Thermo Fisher Ampliseq™ Cancer Hotspot Panel v2 on the Ion Torrent PGM™.

    15 previously-characterized FFPE samples found a high degree of concordance (90.0%, 27/30 variants), and the Pillar Biosciences’ assay was shown to be highly reproducible at 5 ng and 50 ng input DNA. Allele frequency measurement reproducibility was also evaluated.

    J. Peterson, F. Blumental de Abreu, Z. Wang, W. Wells, G. Tsongalis, “Evaluation of the Pillar NGS SLIMamp Lung and Colon Hot Spots Panel”. Dartmouth-Hitchcock Medical Center, Lebanon, NH; Pillar Biosciences, Natick, MA

    Register to Download